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J Hardy Selected Research

Spastic Paraparesis

11/2001Cotton wool plaques in non-familial late-onset Alzheimer disease.
5/2001Variant Alzheimer disease with spastic paraparesis: neuropathological phenotype.
3/2001A pathogenic presenilin-1 deletion causes abberrant Abeta 42 production in the absence of congophilic amyloid plaques.
11/2000Variant Alzheimer's disease with spastic paraparesis and cotton wool plaques is caused by PS-1 mutations that lead to exceptionally high amyloid-beta concentrations.
3/2000Variant Alzheimer's disease with spastic paraparesis: clinical characterization.

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J Hardy Research Topics

Disease

24Alzheimer Disease (Alzheimer's Disease)
01/2019 - 03/2000
15Parkinson Disease (Parkinson's Disease)
10/2007 - 06/2000
9Parkinsonian Disorders (Parkinsonism)
12/2016 - 06/2000
8Neoplasms (Cancer)
10/2017 - 03/2000
6Frontotemporal Dementia (Semantic Dementia)
01/2016 - 08/2000
5Dementia (Dementias)
10/2016 - 06/2000
5Spastic Paraparesis
11/2001 - 03/2000
4Cancer Pain
10/2017 - 04/2002
4Pain (Aches)
05/2015 - 12/2001
4Vomiting
04/2011 - 12/2001
4Nausea
04/2011 - 12/2001
3Genetic Risk Score
01/2021 - 01/2018
3Cognitive Dysfunction
01/2021 - 08/2001
3Neuralgia (Stump Neuralgia)
10/2017 - 12/2005
3Neurodegenerative Diseases (Neurodegenerative Disease)
12/2010 - 09/2001
3Fatigue
12/2001 - 05/2000
2Pantothenate Kinase-Associated Neurodegeneration (Hallervorden-Spatz Disease)
02/2013 - 06/2009
2Tauopathies
12/2010 - 01/2006
2Synucleinopathies
03/2007 - 01/2006
2Pick Disease of the Brain (Pick's Disease)
08/2002 - 08/2000
2Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome)
08/2002 - 08/2000
2Breast Neoplasms (Breast Cancer)
11/2001 - 05/2000
2Amyloid Plaque
05/2001 - 03/2001
2Prostatic Neoplasms (Prostate Cancer)
06/2000 - 05/2000
1Sinusitis
05/2020
1Chronic Pain
01/2017
1Cachexia
12/2016
1Sepsis (Septicemia)
12/2016
1Carcinoma (Carcinomatosis)
06/2016
1Necrosis
06/2016
1Pseudohypoparathyroidism
01/2016
1Hyperphosphatemia
01/2016
1Hypocalcemia
01/2016
1Critical Illness (Critically Ill)
03/2015
1Hyperlactatemia
03/2015
1Hypertension (High Blood Pressure)
03/2015
1Astrocytoma (Pilocytic Astrocytoma)
05/2014
1Pruritus (Itching)
05/2014
1Antiphospholipid Syndrome (Antiphospholipid Antibody Syndrome)
01/2014
1Neurodegeneration with brain iron accumulation (NBIA)
02/2013
1Neuroaxonal Dystrophies (Neuroaxonal Dystrophy, Late Infantile)
02/2013
1Dystonia musculorum deformans type 1
10/2012
1Granuloma
05/2012
1Communicable Diseases (Infectious Diseases)
02/2012
1Incisional Hernia
08/2011
1Hernia (Hernias)
08/2011
1Multiple System Atrophy
03/2009
1Death (Near-Death Experience)
05/2008
1Bipolar Disorder (Manic Depressive Psychosis)
02/2008

Drug/Important Bio-Agent (IBA)

11alpha-SynucleinIBA
08/2005 - 06/2000
7Presenilin-1IBA
01/2002 - 03/2000
6Apolipoproteins E (ApoE)IBA
01/2018 - 12/2000
6Proteins (Proteins, Gene)FDA Link
10/2012 - 09/2001
5Dopamine (Intropin)FDA LinkGeneric
12/2016 - 08/2000
5tau Proteins (tau Protein)IBA
01/2016 - 08/2000
5Amyloid (Amyloid Fibrils)IBA
03/2014 - 12/2000
4Biomarkers (Surrogate Marker)IBA
01/2021 - 09/2000
4ApolipoproteinsIBA
12/2013 - 09/2000
4Amyloid beta-PeptidesIBA
11/2001 - 03/2000
3Opioid Analgesics (Opioids)IBA
01/2017 - 04/2002
3PresenilinsIBA
08/2005 - 10/2000
2DNA (Deoxyribonucleic Acid)IBA
01/2021 - 05/2012
2Apolipoprotein E4IBA
01/2019 - 12/2000
2Pharmaceutical PreparationsIBA
10/2016 - 05/2001
2Analgesics (Analgesic Drugs)IBA
05/2015 - 12/2005
2AntibodiesIBA
01/2014 - 06/2000
2SynucleinsIBA
02/2013 - 12/2010
2Methotrimeprazine (Levomepromazine)FDA Link
04/2011 - 09/2005
2IronIBA
06/2009 - 08/2000
2ProgranulinsIBA
07/2007 - 07/2007
2Levodopa (L Dopa)FDA LinkGeneric
12/2005 - 02/2001
2Antipsychotic Agents (Antipsychotics)IBA
12/2005 - 09/2005
2Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA
08/2005 - 08/2000
2Flavin-Adenine Dinucleotide (FAD)IBA
03/2001 - 10/2000
2Peptides (Polypeptides)IBA
12/2000 - 03/2000
1Apolipoprotein E2IBA
01/2019
1propylene diquat (PDQ(+))IBA
10/2017
1Ascorbic Acid (Vitamin C)FDA LinkGeneric
01/2017
1Methotrexate (Mexate)FDA LinkGeneric
12/2016
1Technetium (Technetium 99m)IBA
06/2016
1Parathyroid Hormone (Parathormone)IBA
01/2016
1Lactic Acid (Lactate)FDA LinkGeneric
03/2015
1salicylhydroxamic acid (SHAM)IBA
03/2015
1Capsaicin (Zostrix)FDA Link
05/2014
1Glycoproteins (Glycoprotein)IBA
01/2014
1Phospholipases A2 (Phospholipase A2)IBA
02/2013
1pantothenate kinaseIBA
02/2013
1CopperIBA
02/2012
1Glucosylceramidase (Glucocerebrosidase)IBA
03/2009
1Diacylglycerol KinaseIBA
02/2008

Therapy/Procedure

5Therapeutics
05/2020 - 06/2000
5Palliative Care (Palliative Therapy)
12/2005 - 03/2000
3Radiotherapy
12/2005 - 11/2001
2Surgical Amputation (Amputations)
12/2016 - 07/2000
2Drug Therapy (Chemotherapy)
12/2005 - 11/2001
1Perioperative Care
08/2011
1Herniorrhaphy
08/2011
1Critical Care (Surgical Intensive Care)
05/2008
1Sympathectomy (Sympathectomies)
10/2007
1Institutionalization (Institutionalized Persons)
10/2007